Pagets disease and breast cancer

Paget's disease of the breast was described by Sir James Paget in Read about invasive breast cancer. You might have some discharge or bleeding from the nipple. Treatment will depend on the findings. The patient's past medical history includes 30 years of lymphomatoid papulosis, a chronic papulonodular dermatological condition, which has been controlled with long-term methotrexate treatment and folic acid supplementation. Moreover, the patient has been extensively investigated for ongoing neurological symptoms that include paraesthesia of hands and left foot and some gait imbalance but the aetiology remains unexplained to date. In Paget's disease, the most common type of adjuvant therapy is radiation following breast-conservative surgery.
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What Paget’s disease of the breast is

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Paget’s disease of the breast: Clinical analysis of 45 patients

Skin scrapings This involves scraping some cells from the skin of the nipple. Learn more here about breast cancer. Case presentation We present the case of a year-old Caucasian man with lymphomatoid papulosis who was diagnosed with Paget's disease of the nipple and who was treated successfully with surgery alone. Cancer cells disrupt the normal epithelial barrier and extracellular fluid accumulates on the surface of the skin, resulting in the crusting of the areola skin. Some women appear to be more at risk of developing breast cancer, but not specifically Paget's disease. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. During a physical examination, the doctor examines the unusual areas of the breast, especially the appearance of the skin on and around the nipples and feeling for any lumps or areas of thickening.
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Paget's disease of the breast | Irish Cancer Society

The nipple and areola often become scaly, red, itchy, and irritated. Imaging may show subareolar microcalcifications, architectural distortion or nipple changes such as thickening [ 7 ]. It will also include contact details for specialist staff, such as your breast care nurse. Show references AskMayoExpert. If breast cancer is present, the doctor will recommend treatment depending on the characteristics and stage of the condition. Only 5 patients manifested a mass with no eczematiod change.
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DF performed the literature search, gathered and analysed the relevant test results and wrote the report. Paget's disease of the nipple with no associated tumour is staged as carcinoma in situ. Limit postmenopausal hormone therapy. A look at nipple fissures, cracks in the skin of the nipple and areola. A wide range of conditions can trigger a rash, and many are harmless.
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